We’re not going to lie; this night treatment boasts a bananas price tag. But if you have the budget, you’ll be happy to know that the patented retinol, whipped up by the namesake surgeon, is the most gentle you’ll find anywhere and the jar is like a time machine for your skin, taking you back to a time in your life before lines, hyper-pigmentation, and dullness.
Recently, Yamaguchi and colleagues (2005) have investigated the potential of inorganic nanoparticles of tretinoin produced by boundary-organized reaction. As observed earlier, tretinoin encapsulation in nanoparticles resulted in significantly less irritation and inflammation as compared with conventional formulation. In addition, nanoparticulate tretinoin showed drastic improvement in photostability as compared with conventional formulation, which was retained even after 46 days of storage. However, the most striking results were observed in the ex-vivo studies.
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I’ve been using this product off and on for about a year and a half. I noticed a huge difference when I wasn’t using it so it has become an absolute necessity over the past few months. My sister once mentioned to me that I had “accordion eyes,” meaning that they wrinkled up like an accordion when I would smile (she’s a jerk, I know). Since using this with consistency, the lines around my eyes have been reduced tremendously! It doesn’t completely get rid of lines (in my opinion, nothing will) but I’ve had a noticeable improvement and this will continue to be a staple in my beauty regimen.
Vitamin A acute toxicity occurs when an individual ingests vitamin A in large amounts more than the daily recommended value in the threshold of 25,000 IU/kg or more. Often, the individual consumes about 3–4 times the RDA’s specification. Toxicity of vitamin A is believed to be associated with the intervention methods used to upgrade vitamin A levels in the body such as food modification, fortification and supplementation, all of which are employed to combat vitamin A deficiency Toxicity is classified into two categories: acute and chronic toxicities. The former occurs few hours or days after ingestion of large amounts of vitamin A accidentally or via inappropriate therapy. The later toxicity (Chronic) takes place when about 4,000 IU/kg or more of vitamin A is consumed for a prolonged period of time. Symptoms associated with both toxicities include nausea, blurred vision, fatigue, weight-loss, menstrual abnormalities etc.
After adjustment for age, examination year, body mass index (BMI), systolic blood pressure, smoking, serum low-density lipoprotein cholesterol, diabetes and history of stroke, men in the highest quartile of serum lycopene concentrations had 59% and 55% lower risks of ischemic stroke and any stroke compared with men in the est quartile; [alpha]-Carotene, [beta]-carotene, [alpha]-tocopherol and retinol were not related to the risk of strokes.
If you’re at all concerned about trying to slow down the effects of aging on your skin, you’ve probably heard of retinol. Retinol is the scientific term for vitamin A and it is proven to increase the production of skin-plumping collagen, thus increasing the firmness and elasticity of skin and softening the depth and overall appearance of wrinkles over time. Retinol is also an antioxidant that helps to counteract the effects of free radicals — which damage skin cells. Most people have no problems using over-the-counter wrinkle creams containing retinol, and are thrilled with the results.
Draelos (2005) recently conducted a controlled clinical trial to evaluate the efficacy of retinol (0.3%) and hydroquinone (4%) in the treatment of photoaging in comparison with 0.05% tretinoin emollient cream. Interestingly, the retinol – hydroquinone combination diminished the collective signs of photodamage more effectively than 0.05% tretinoin emollient cream in terms of dyspigmentation, fine wrinkles, and tactile roughness within 16 weeks of treatment. Feinberg and colleagues (2004) evaluated the efficacy of retinol (0.1%) and glycolic acid (8%) combination in comparison with the individual agents in the treatment of photoaging using the photodamaged arm methodology. They observed that retinol-glycolic acid combination offered significant improvement in the appearance of photoaged skin compared with glycolic acid or retinol alone.
Tretinoin was the first retinoid approved by the FDA to treat wrinkles. This prescription retinoid works by increasing the making of new collagen. It also stimulates new blood vessels in the skin, giving skin a rosy appearance, fading age spots, and reducing precancerous skin spots called actinic keratosis. Tretinoin also may help prevent more serious effects of ultraviolet radiation.
In the evening, apply a pea-sized amount of this retinol cream to clean skin, avoiding the eye area. Allow for absorption before applying other skincare products. Limit initial use to once or twice a week, gradually increasing frequency to every other night, and the every night as tolerated. It is recommended for new retinol users to start with SkinCeuticals Retinol 0.5.
I haven’t had any irritation and I am pretty sensitive. Meanwhile, if I don’t put this on after cleansing my eyes feel really dry. I considered the Neutrogena one as well but more people mentioned wrinkles deepening and that worries me. I also have no packaging issues. I roll the metal up as I go to maximize product and keep it from cracking.
Retinol is the #1 dermatologist recommended cosmetic age-fighting ingredient. A derivative of Vitamin A, retinol works to unclog pores, boost collagen to reduce fine lines, and speed cell turnover to even out discolorations and smooth the skin. RoC® scientists were the first to develop the methods needed to stabilize and package retinol in its pure and effective form.
Talking Top Tens: Marissa GibbonsMarissa Wilson Gibbons is co-founder and CEO of Riley & Grey, a next-level wedding tech company, bringing a fresh perspective to the bridal space. Follow Riley & Grey and Marissa on Instagram.
But the benefits don’t stop at the surface. According to Patricia Farris, M.D., a clinical associate professor of dermatology at Tulane University, in New Orleans, retinoids also boost the production of collagen (one of the skin’s primary support structures) and prevent its breakdown as they work their way into deeper skin layers. There is evidence, too, that retinoids foster the creation of glycosaminoglycans, substances found in the body that help keep tissues hydrated. And, wait, there’s more: Retinoids help clear dead skin cells, oil, and debris from pores, leaving them less distended; retinoids even decrease oil production—a boon to those prone to breakouts.
There are literally thousands upon thousands of creams and serums out there that all promise to turn back the clock and other wishful claims, but at this point there’s only one super ingredient that really delivers on such promises. That would be retinoids, friends. (Both over-the-counter retinol and its prescription counterpart Retin-A both fall under this category.) While it was initially used to get rid of acne, blackheads and dead cell buildup in pores, retinol was also found to have incredibly effective anti-aging properties.
I’m 55 yrs old. I’ve been using this product for about 6 months. I bought it because I was tired of paying over $100 for department store products and I figured it couldn’t hurt to try something new. All I can say is that my skin looks great. It’s tight, it’s clear, and it has a healthy glow. I’m attaching a photo I took a couple of weeks ago (keep in mind that I’m 55 so my skin isn’t perfect) but I think it looks pretty good. I also love the fact that I don’t have to be stingy with it due to it’s affordability; I use it on my face and neck twice a day. I also use Lilyana Natural Rosehip and Hibiscus Eye Cream, for the record. I’ve had no cosmetic surgery on my face, which I’m sure you can tell, but overall I think I look pretty good! The product is gentle and pure, so I’ve not experienced any ill effects with it. I hope this review helps you to feel comfortable with purchasing this great, affordable product.
Though waking up with puffy eyes happens to many, dark circles and under-eye puffiness can start to linger or become more noticeable due to age and the breakdown of fat and collagen. Retinol helps with cell turnover and collagen synthesis, and can be used for restoring and reviving skin around your eyes. There are many eye creams available that contain retinols to help you look rested and refreshed, along with other ingredients to soothe the sensitive skin in the eye area.
This Best of Beauty winner has served as a gateway retinoid for more friends and colleagues than we can count. The brand invented its own molecule by combining the retinoid vitamin A with lactic acid, a moisturizing form of the exfoliant AHA. Using double-conjugated bonds to create the molecule AlphaRet, they were able to allow for a gradual release of both the retinoid and the lactic acid into the skin, helping to counter irritation. “Because it takes time for the body to break down [this hybrid molecule], the skin doesn’t feel the actives as much,” says cosmetic chemist Ni’Kita Wilson. (Built-in soothers, like ceramides, squalane, and bisabolol, help keep the peace.) What’s more, by dissolving dull surface cells, the lactic acid begins brightening skin after only a night or two, so “you get both the instant boost of exfoliation plus the long-term repair from the retinoic acid,” she adds. In a company-funded 12-week clinical study, the cream improved fine lines, pigmentation, and pore size as effectively as .025 percent tretinoin, and worked better than a 1 percent retinol cream while stirring up less irritation.
After we cut the bad stuff, we wanted to know about the good stuff (aka the most effective ingredients). We reached out to our experts and found that it really depends on what you want your eye cream to do. There are three major issues that eye creams seek to address: wrinkles, dark circles, and puffiness. And, what is a good ingredient to target for one issue, shouldn’t be used in combination in the same product for another.
This light-weight RoC®RETINOL formula helps to improve the appearance of fine lines and deep wrinkles. After four weeks, skin appears more radiant, fine lines are smoothed and skin firmness is improved. After eight weeks, crow’s feet are visibly reduced and discoloration is diminished. After 12 weeks, deep wrinkles are visibly reduced. This formula glides on easily and absorbs quickly, leaving your skin feeling smooth and velvety and is ideal for use under makeup.
Though retinols generally take a minimum of four months to produce results, we didn’t have two years to test this smack down—plus, in the end, all retinols have the same effect on your skin, regardless of their concentration—so we instead based our rankings on the formula’s texture, packaging, application, and its feeling on your skin. (If you hate any of those factors, you definitely won’t stick with a retinol routine every few days for a year.)
Something else to consider is that retinol, like all vitamin A derivatives, is NOT recommended for women who are pregnant or breastfeeding. That includes all skin care products, even serums and night creams. And it certainly includes sunscreens – I’m always appalled when I see pregnant women applying retinol-containing sunscreens on their bellies. I can’t understand why warnings for pregnant women are not on more skin care products.
So which retinol cream is right for you? We recommend LifeCell All-in-One Anti-Aging Treatment. It has just the right amount of retinol to ensure those wrinkles you hate will be gone in no time. It’s by far our favorite retinol cream on the market. It’s odor-free and paraben-free. In addition to that, it’s also hypoallergenic, perfect for those of us with sensitive skin. One tube lasts much longer than any other cream we’ve ever tried, because you only need a dime-sized amount for it to work at its full potential. . It’s been over 3 months and we still have ours!